COVID-19 infection is a public health challenge that also includes the issue of health inequity in the United States and around the world. Populations in underserved communities and those who have underlying conditions (obesity, diabetes, hypertension, etc...) experienced higher rates of SARS-Cov-2 infection, hospitalizations, and even deaths. Traits such as obesity, diabetes, and hypertension associated with the severity of the SARS-Cov-2 pandemic made physical activity interventions a valuable prevention factor. Physical activity improves body composition and patients' metabolic, cardiorespiratory, and mental health, enhancing antibody responses when vaccinated. In addition, it boosts brain health, helps manage weight, reduces the risk of disease, especially chronic diseases (hypertension, diabetes, etc..), strengthens bones and muscles, and improves the ability to do everyday activities. This systematic literature review aims to combine the findings of the currently published articles regarding the change in SARS-Cov-2 infection symptoms among physically active peopleand the association between physical activity before the Coronavirus Disease 2019 infection and the severity of illness and mortality in the adult population. Methods: Information was gathered through the PubMed and Medline databases conducted in November 2023. The inclusion criteria are composed of observational studies examining the impact of regular physical activity on SARS-Cov-2 symptoms in adult populations worldwide. Article reviews, experimental studies, case reports, and series were excluded. A total of 926 articles were found, and only fifteen studies were included in this systematic literature review. Results: Fifteen articles were included in this systematic literature review and the findings demonstrated that physical activity helps patients infected with SARS-Cov-2. Physical activity before infection might reduce the severity and mortality of patients, especially in physical activity ≥ 150 min/week of moderate activity or ≥75 min/week of vigorous activity. Engaging in regular and sustained, even in different patterns of physical activity, has beneficial effects on the severity of COVID-19 infection and symptoms in adults. Conclusion: Overall, physical activity contributes to decreasing COVID-19 infection symptoms promotes recovery of physical function, alleviates post-acute COVID-19 syndrome, and improves patients' psychological well-being.
