Chemoprevention of dmba induced skin carcinogenesis in swiss albino mice by quinine sulfate

7, 12-dimethylbenz (a) anthracene induced and croton oil promoted mouse skin carcinogenesis is a useful murine model to show genetic and biological changes involved in tumor promotion, and also for selecting of new cancer protective agents, because this model displays a preneoplastic condition during carcinogenesis in the form of papillomas, which are easily visible. The aim of this study is to show the effect of quinine sulfate against skin cancer in Swiss albino mice (Mus_musculus).Oral administration of the Quinine sulfate at the dose rate of 12 mg/kg body weight showed a significant reduction in the tumor burden, tumorweight, tumor size and cumulative number of tumors. Moreover there was decrease in the number of tumor bearing mice and their onset of tumors. These findings suggests the protective effect of Quinine sulfate in skin cancer but a little higher dose 15 mg/kg body weight did not show protective effect.