The mathematical models used to determine the kinetics of drug release from drug delivery systems. The quantitative analysis of the values obtained from dissolution/release rates is easier when mathematical formulas are used to describe the process. The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various kinetic release models. Mathematical models for the drug release studies play an important role as it establishes a mechanism of drug release and provides general guidelines for the development of other systems. It is accepted that numerous successful drug delivery systems have been developed as a result of an almost arbitrary selection of components, configurations and guidelines. This review gives them an idea about the current state of mathematical (kinetic) modeling of drug delivery including empirical/semi empirical and mechanistic release models.
