The research identifies the students' challenges in their learning process and how these challenges impact their patient care practices. Results showed that the respondents’ knowledge is not influenced by their perception and the challenges they face in online learning. It is seen that the student’s knowledge based on their grades does not affect their perception of providing patient care. Therefore, there is no significant relationship between the students' knowledge and their perception of providing patient care. This research sheds light on the gaps in nursing education and highlights the need for a more holistic approach to nursing education that goes beyond knowledge acquisition. The study's conclusions showed no correlation between nursing students' perceptions of their knowledge gaps and their difficulties in learning about patient care. Despite being proven to be unrelated, several of the three variables have been shown to be significant. The research provides recommendations for nursing students, educators, and institutions on addressing these challenges and improving the quality of nursing education to prepare students for their future roles as healthcare providers. Ultimately, this research aims to contribute to the development of competent nursing professionals who can provide quality care to their patients.