Vaccination not only reduces the risk of short- and long-term health complications from COVID-19, but it also slows or stops the spread of the disease by preventing it from being passed onto others that are at high-risk for severe COVID-19 illness, like grandparents or daycare staff with underlying medical conditions. The pace of the COVID-19 vaccine development process is unprecedented and is challenging the traditional paradigm of vaccinology science. The main pressure comes from the pandemic situation, but what makes it possible is a complex set of factors and innovative environments built overtime, which this manuscript aims to review.The development of COVID-19 vaccines has been one of the most significant scientific achievements in recent history. Since the outbreak of the pandemic, researchers worldwide have been working tirelessly to develop safe and effective vaccines to protect against the virus. The vaccines have been developed using innovative technologies, such as mRNA, and have undergone extensive clinical trials to ensure their safety and efficacy.