Infectious diseases are recognized for the maximum mortality as well as morbidity of humans and animals. The higher prevalence of infectious diseases is found in low- and middle-income countries (LMICs). This is due to poor sanitization and hygienic condition which is favorable for the growth of pathogenic microorganisms. The present study focused on the current status of major infectious diseases in Northern India. Overall results indicated that the prevalence of selected diseases still remains similar to previous studies with several changes in their severity. This study finally concluded that in Northern territory of India has poor sanitary conditions. Moreover, only a few scientific studies addressing the various issues related to these infections and there is urgent need for numerous studies that provide the actual state of infections.