According to the outcomes of a clinical experience in more of two hundred patients, pressure focused on the wound bed prevents infection. We did a daily follow-up of the clinical course of the wounds, during the first few weeks, to detect any signs or symptoms of infection, in which case we would prescribe antibiotics, but this did not happen. We asked for cell cultures of the wound’s exudate, finding bacterial contamination, but no infection. The explanation lies in the antibacterial effect of monocytes. due to increased blood flow from arteriogenesis, stimulated by focused pressure on the wound bed. We reported a clinical case of an 80-year-old woman with venous hypertension who suffered trauma to her right leg. The first cures were made in the emergency of primary care and, as the wound did not heal, he asked for consultation, eleven days later. We applied, only eight days, double focal compression bandaging technique, because the patient considered that the clinical course was not adequate so, she went to the emergency department of the hospital. She was admitted to the hospital for 19 days, treated with intravenous antibiotics for 8 days, and discharged from the hospital to be treated for home hospitalization. The ulcer healed 4 months later. This article highlights the anti-infective effect of the focused pressure on the wound bed, comparing this case with three similar ones, in which wound/ulcer healing was achieved using only the focused pressure on the wound bed.