In this era of information technology, the role of teachers is changing from providing information to organizing the entire learning process. This is mainly because, learners can easily access any information they need by use of instructional technologies such as Internet, Mobile phones and graphics, unlike in the past where text books were the only source of information. Technology is very essential in the instruction of students in secondary schools today and this is especially so in a developing country like Kenya. Instructional technologies enhance mastery of the content, provide information as comprehensive as possible in different formats and provide teachers with a variety in presentation of content. The rationale was based on the view that properly designed learning materials inspired by instructional technology and delivered by technology add value to a teaching situation where contact hours are limited. The curriculum needs, academic standards and the development of digital age skill for the 21st century learners. The literature review focused on the meaning and use of instructional technologies in teaching and learning in institutions in Kenya and other parts of the world. However, it did not address the use of instructional technologies in secondary schools. This was a descriptive survey design. Despite the importance of instructional technologies, Kenyan secondary schools face challenges. A study was conducted in ten purposively selected secondary schools in Kisii Central District, Kisii County between March 2011 and March 2012. Data was collected using questionnaires, interview schedules and observation schedules. The obtained data were analyzed systematically using descriptive statistics and presented with the help of frequency tables, graphs and percentages. The study findings revealed that teachers were influenced by availability of instructional technologies, knowledge and skills in use. Findings also revealed myriads of challenges faced by teachers and students. Finally, it is paramount that teachers plan teaching, and learning which applies technology to maximize students learning.