Comparison of the effects of intrathecal bupivacaine, levobupivacaine and ropivacaine in lower abdominal surgery: a double-blind, randomized controlled trial using isobaric preparations

Background: Though various local anesthetic agents are widely used intrathecally for lower umbilical surgeries, their efficacy vary even when used in equipotent doses. Objective: The present study has been conducted to compare the efficacy of intrathecal bupivacaine, levobupivacaine and ropivacaine in lower umbilical surgery using isobaric preparations. Study design: Double-blinded randomized controlled trial. Total 93 patients of ASA (American Society of Anesthesiologists) physical status I and II, all female, aged between 18 to 60 years, were randomized into 3 groups receiving 3 ml of 0.5% bupivacaine, 0.5% levobupivacaine and 0.75% ropivacaine in intrathecal route. Results: Between bupivacaine and levobupivacaine groups, there was no significant difference in any parameter (p>0.5) but ropivacaine group had overall delayed onset and early recovery in several parameters. Conclusion: Intrathecal bupivacaine and levobupivacaine showed superior efficacy. We recommend levobupivacaine owing to its safer cardiac profile.

Dr. Ashok Das, Dr. Rajdip Hazra, Dr. Bivash Halder, Dr. Susmita Ghosh, Dr. Sisir Chakraborty, Dr. Rajarshi Basu, Dr. Swadesh Garain and Dr. Sumanta Dasgupta
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