The hazards of Strangles and Gastrointestinal parasites is major problems in equine farms.They cause losses and complications among ponies and aged horse. This study was concerned with the prevalence of atypical mild Strangles, GIT parasites, significant EPG and antimicrobial resistance Streptococcus equi subsp. equi. In equine farm. Nasal swab and faecal samples were collected from six stables in Horse farm (N = 37 horses) at summer’s season 2015. Isolation and identification of S. equi colonies were done according to culturing characters, Gram’s staining, biochemical methods and Lancefield grouping. Faecal examination was applied by Sedimental-centrifugal flotation method to identify GIT eggs. The faecal egg counts (EPG) were performed using amodifiedMcMaster technique. The overall prevalence of strangles was 70.3 % (26/37). Atypical Mild non-cured drug resistance Strangles prevalence were 23 % (6/26).The overall prevalence of GIT parasite was 45.9 % (17/37) in all horse stables.GIT parasites cases (EPG ≥ 200) were 58.8% (10/17). Isolated Streptococcus equi subsp. equiwere significantly higher sensitive to Ciprofloxacin (5μg) (100 %). Isolated colonies were completely resistant to Sulfamethoxazole and Trimethoprim (SXT), Ampicillin (AMP), Gentamicin (CN), Ceftriaxone (CRO), Amoxicillin &Clavulinic acid (AMC) and Cephradine (CE). In conclusion, GIT parasites was significantly higher in young and old horses. Furthermore, atypical mild drug resistance Strangles case significantly higher in GIT parasites case (EPG ≥ 200).