This Normal pregnancy is considered as hypercoagulable state; a physiological safety aimed at preventing excessive maternal blood loss at delivery. The study aimed to evaluate the influence of normal pregnancy on coagulation profile (PT, APTT and TT) Platelet count and to explore changes in activity from the first through the third trimester. This case control study was performed in consult center in Sudan. A total of forty five (45) apparently healthy pregnant women (15 from each trimester) and 30 healthy non-pregnant age-matched controls were recruited. Each participant had Prothrombin time (PT). Activated partial thromboplastin time (APTT), Thrombin time and platelet count were done. Multiple comparisons were made between control values and coagulation profile at different stages of pregnancy by using the statistical package for social sciences (SPSS) version 11.5, Results were expressed as means and standard deviations, p < 0.05 was significant at 95 % CI. The study revealed that a significant differences in mean and P value of two groups, Platelet count were significantly decrease in pregnant women as the P value was (0.02), PT, APTT also showed lower value than in non pregnant women as the P value was (0.003 and 0.001), while Thrombin time remain at non-pregnant levels as the P value was (0.18). APTT and Platelet count were affected by gestation stage but PT was not. The means of the APTT was lower in the first, second and third trimesters compared with controls (34.1 seconds, 31.6 seconds and 29.1 seconds, respectively, vs. 39.4 seconds for control ) Correspondingly, the platelet count was reduce in the first, second and third trimesters compared with controls (257x 10(9) /L 207x 10(9)/L, 193 207x 10(9)/L respectively, vs. 289x 10(9)/L for control group . Conclusion: The APTT and platelet counts are significantly lower in the 3 trimester of normal pregnancy.
