Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of plasmalipid level in steady-state children with SCD, once that this lipid marker has been correlated with hematological parameters . Methods: We prospectively analyzed plasma lipid profile and hematological biomarkers of 50 steady-state infants with SCD in Sudan, Khartoum state mindary BA88A made in china . Clinical data were collected from patient medical records. Results: This study was done to determine the plasma lipid profile in sickle cell anaemia patients. Fifty sickle cell anemia (HbSS) patients aged 9-17 years were used for the study. The plasma cholesterol (172.9±30.2 mg/dl) in sickle cell anemia were significantly decreased (p<0.05) when Also the serum high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol in sickle cell anaemia (65.0±31.0 mg/dl and 68.0±14.9 mg/dl) were significantly decreased (p<0.05). There is no significant variation in the mean level of triglyceride in sickle cell disease. This result shows that sickle cell disease patients are not prone to coronary heart disease. Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemicsubphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis.