Background: vaso-occulusive event in pediatric sickle cell disease (SCD) may cause renal complication such as urinary concentrating defects, impaired urinary acidification, proteinuria, and hematuria. Chronic sickling promotes different mechanism of kidney injury. Iron accumulation due to hemolysis can cause various organ damage. Objective: the study aimed to asses proteinuria, hematuria, urobilinogenuria and ferritin levels as indicators of sickle cell nephropathy (SCN) Materials and Method: this is a cross sectional study, conducts in DrGaafarIbnauf Pediatric Tertiary Hospital in KHARTOUM, SUDAN from December 2016 to February 2017. It included a fifty pediatric in steady state of disease, with history of multiple blood transfusion, in administration of hydroxyuria and without chronic renal failure. The patients were screening for Kidney involvement features such as proteinuria, hematuria, and urobilinoge, in relation to anemia degree and hemolysis marker such as, hemoglobin and reticulocyte, and ferritin level Results: prevalence of renal complication in our cross sectional study in pediatric sickle cell disease (mean age 3.8±1.1years) was found to be relatively high, predominately proteinuria (46%), hematuria (8%), and urobilinogenuria (10%). Urine concentration ability show an acidic urine, pH was 5.52±0.50 and low specific gravity value 1.00±0.01. Ferritin was show high level 451.01±392.17ng/ml. Conclusion: In this studyin SCD. We observed proteinuria frequently detected, and less extent hematuria and urobilinogen, also high Iron concentration is a common feature.