Abstract: The issue of patient safety has been brought to the attention of the medical community in 1999 through a report of the US Institute for Medicine titled “To Err Is Human.” In 2004, the World Health Organization launched the initiative “Patient safety – a Global Challenge” and established the World Alliance for Patient Safety. Owing to scientific progress, many new medications are being introduced in the market. In result of this “medicinal explosion,” a need arises for the health specialists to inform their patients about any possible adverse drug reactions (ADRs) and to report about any suspected new ADRs. Objective: This article intends to trace one aspect of patient’s safety related to the use of medications, and this is the reporting of Adverse Drug Reactions (ADRs). Methods and materials: We conducted an anonymous survey among the medical specialists (physicians and chemists) in the territory of Varna, Bulgaria with regard to the frequency of ADRs reported by them. Results: All specialists take into consideration the risks inherent to the use of medications and all specialists share that they observe ADRs in their practice; however, all respondents unanimously shared that they did not report about observed ADRs neither on the page of the Bulgarian Drug Agency, nor though the Yellow Card.