The present research program was carried out to investigate the antihelmintic activity of the aqueous and ethanolic extract of Cucumis dipsaceus against adult Indian earthworm Pheritima posthuma. Various concentrations (25, 50, 100mg/ml) of ethanolic extract evaluated for antihelmintic activity by recording the time required for paralysis and death of worms. Albendazole was used as standard. Result indicates ethanolic extracts of Cucumis dipsaceus significantly (p<0.01) exhibited antihelmentic activity in dose dependent manner when compared with standard. The shortest time required for paralysis and death was observed with concentration of 100mg/ml. Further studies are under progress to confirm the possible chemical constituents responsible for activity.