Background: Female infertility either primary or secondary type is a multifactorial condition. It constitutes a worldwide public health problem that has gained much concern during the past two decade. Causes and risk factors of infertility can be classified into: genital, endocrinal, developmental and general factors .Overall aim of the study was to identify the risk factors of infertility among Sudanese women. Materials and methods: Multi center-based cross sectional descriptive study design was conducted at Khartoum state .the total number of participants enrolled in this study mounted to 162 infertile women. Data were collected using standardized administered questionnaire to assess risk factors associated with infertility among Sudanese women .SPSS version 16 was used to analyze the collected data. Results: Distribution of participants by age in years showed there is no significant association with type of infertility p value (0.747), also found that significant relation between current occupation and type of infertility p value (0.01), regard distribution of participants by smoking and type of infertility seen strong association p value (0.007). Distribution of participants by ever been subjected to circumcision and type of infertility revealed no significant relation P value (0.41). Distribution of participants by family history of infertility illustrated strong association with type of infertility P value (0.004) and distribution of participants by uterine fibroids showed highly significant association with type of infertility P value (0.000) Conclusion: Most common risk factors of female infertility in this study are family history of infertility; current Occupation, uterine fibroids and smoking were strong associated by types of infertility. Female circumcision and age was not associated by types of infertility among Sudanese women.