Cervical cancer is the second most common cancer in women worldwide and the third among the female population in Iran. HPV plays an important role in the development of cervical cancer, being present in 95% of cases of cancer of the cervix. We report a case of Simultaneous Existence of HPV- High-risk types 45, 51, 52 and Low-risk 42 – Related Cervical Cancer in a Patient. We also discuss the clinical features of the disease, its Histopathological findings, and treatment and rigorous follow-up. HPV was diagnosed after DNA extraction from paraffin blocks of DNA HPV by PCR with primers. HPV type 45, 51, 52, 42 was found in a patients. Results of the study confirm the previous reports concerning the relationship between HPV and cervix cancer.The case study showed that a patient could at the same time there is HPV- High-risk types 45, 51, 52 and Low-risk 42 - Related Cervical Cancer.