The prevention of dental caries and periodontal disease can be achieved with meticulous removal of dental plaque. Oral hygiene practices differ from country to country and from culture to culture on the basis of religious beliefs. These beliefs may influence diet, cleaning aids or the use of home remedies for oral hygiene. The use of natural plant sticks for teeth cleaning is one common fact practiced in different cultures. Among these natural brushes, Miswak stick holds the most historical and therapeutic values in literature. This review article discusses the therapeutic properties of Miswak and their effect on oral health.